Oxycodone And Acetaminophen (Oral Route) Proper Use (2024)

Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming and cause mental or physical dependence. Also, large amounts of acetaminophen may cause liver damage if taken for a long time.

It is very important that you understand the rules of the Opioid Analgesic REMS program to prevent addiction, abuse, and misuse of oxycodone and acetaminophen combination. This medicine should also come with a Medication Guide. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.

You may take this medicine with or without food.

Measure the oral liquid using the patient cup that comes with the package.

Swallow the extended-release tablet whole with water. Do not crush, break, chew, dissolve, snort, or inject it. Do not pre-soak, lick, or wet the tablet before placing it in your mouth. Do not give this medicine by feeding tubes.

Check with your doctor first before changing dosage forms (eg, capsules, extended-release tablets, tablets). These forms are very different from each other.

This combination medicine contains acetaminophen (Tylenol®). Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For moderate to moderately severe pain:
    • For oral dosage form (capsules):
      • Adults—1 capsule every 6 hours as needed.
      • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (extended-release tablets):
      • Adults—2 tablets every 12 hours as needed.
      • Children—Use is not recommended.
    • For oral dosage form (solution):
      • Adults—5 milliliters (mL) or 1 teaspoon every 6 hours as needed. Your doctor may adjust the dose as needed. However, the dose is usually not more than 60 mL (12 teaspoons) per day.
      • Children—Use and dose must be determined by your doctor.
    • For oral dosage form (tablets):
      • Adults—1 or 2 tablets every 6 hours as needed.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of Percocet®, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines. Make sure you store the medicine in a safe and secure place to prevent others from getting it.

Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website:www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm .

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  • Before Using
  • Precautions

Portions of this document last updated: May 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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Oxycodone And Acetaminophen (Oral Route) Proper Use (2024)

FAQs

Oxycodone And Acetaminophen (Oral Route) Proper Use? ›

For oral dosage form (oxycodone and acetaminophen tablets): Adults—1 tablet (7.5 milligrams (mg) of oxycodone and 325 mg of acetaminophen) every 6 hours as needed. Your doctor may adjust your dose as needed. However, the dose is usually not more than 8 tablets per day.

How do you take acetaminophen and oxycodone? ›

Adults—1 tablet (7.5 milligrams (mg) of oxycodone and 325 mg of acetaminophen) every 6 hours as needed. Your doctor may adjust your dose as needed. However, the dose is usually not more than 8 tablets per day. Children—Use and dose must be determined by your doctor.

How do you administer oxycodone oral solution? ›

Method of administration

Oral use. Oxycodone Hydrochloride G.L. Pharma oral solution should be taken every 4-6 hours based on a fixed schedule at the dosage determined. The oral solution may be taken with or independent of meals with or without an amount of liquid.

What is the route of administration for oxycodone? ›

When provided orally, oxycodone reaches peak serum concentrations within 1 to 2 hours and exhibits half-lives of 2.5 to 4.0 hours. It may be given by alternative routes, such as intramuscularly, intravenously, subcutaneously, and rectally, but these routes of administration are rarely employed.

Can I take oxycodone acetaminophen on an empty stomach? ›

This form of oxycodone is a pill that can be taken with or without food. You should take the pill whole; if you can't, contact your care team. Oxycodone/acetaminophen comes in various dosages. The pill is usually taken either as needed for pain or on a regular schedule decided by your care provider.

How is oxycodone used? ›

The solution, concentrated solution, tablet, and capsule are taken usually with or without food every 4 to 6 hours, either as needed for pain or as regularly scheduled medications. The extended-release tablets (Oxycontin) are taken every 12 hours with or without food.

How do you administer oral solution? ›

Using a medicine cup or spoon
  1. Wash your hands.
  2. Make sure your child is sitting upright.
  3. Shake the bottle unless stated otherwise on the label.
  4. Carefully pour the medicine into the medicine cup or medicine spoon according to the dose on the label.
  5. Give the dose to your child.

When should oxycodone be administered? ›

Adult dosing

Acute pain: Initial recommended doses of oxycodone are in the 5 mg to 15 mg range, every 4 to 6 hours as needed for adequate analgesia of acute pain. Further dosing should be titrated upwards for pain control, with attention and monitoring for adverse effects.

How is oral oxycodone absorbed? ›

The absorption of oxycodone from OxyContin® tablets is biphasic, with an initial absorption of approximately 40% of the active drug (T½ = 0.6 hrs) providing onset of analgesia within 1 hour in most patients, followed by a more controlled absorption, which determines the 12 hour duration of action (T½ = 6.2 hrs).

What pain killer is the strongest? ›

Carfentanil: Carfentanil, a synthetic opioid, is a 100-fold stronger version of fentanyl. It has 5,000 times the potency of heroin and 10,000 times the potency of morphine. There has been an increase in the amount of carfentanil in narcotics, and this substance nearly invariably results in overdose and death.

What are the bioavailability routes of administration for oxycodone? ›

Oxycodone (OxyContin) is another long-acting opioid that is usually administered orally and is available in a controlled-release formulation. The bioavailability is 60% to 86% in adults. Oxycodone may also be administered rectally, with a similar bioavailability, although absorption can be prolonged.

Which is stronger, Percocet or oxycodone? ›

The strength of both Percocet® and oxycodone depends on the formula. For example, 15 mg oxycodone will be stronger than 325 mg/5mg Percocet®. However, if they contain the same amount of oxycodone, Percocet® is usually stronger because it also contains acetaminophen, which boosts its effects.

Can you take Tylenol and oxycodone together? ›

Oxycodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time.

What not to take with oxycodone? ›

This medication may interact with the following:
  • Alcohol.
  • Antihistamines for allergy, cough, and cold.
  • Atropine.
  • Certain antivirals for HIV or hepatitis.
  • Certain antibiotics like clarithromycin, erythromycin, linezolid, rifampin.
  • Certain medications for anxiety or sleep.

How addictive is oxycodone? ›

Individuals who abuse OxyContin risk developing tolerance for the drug, meaning they must take increasingly higher doses to achieve the same effects. Long-term abuse of the drug can lead to physical dependence and addiction.

What pain reliever can be taken with oxycodone? ›

Taking oxycodone with other painkillers

It's safe to take oxycodone with paracetamol, ibuprofen or aspirin (do not give aspirin to children under 16 years of age). Do not take oxycodone with painkillers that contain codeine.

How far apart should oxycodone and ibuprofen be given? ›

Dosages. In combination pill, 5 mg oxycodone and 400 mg ibuprofen every 6 hours as needed.

How do you alternate Tylenol ibuprofen and oxycodone? ›

Give one medicine dose every 3 hours, alternating between acetaminophen and ibuprofen. Give oxycodone as needed for breakthrough pain, pain that is not relieved by acetaminophen and ibuprofen. Wait at least 4 hours between doses of oxycodone.

Can you take acetaminophen with opioids? ›

Opioid medicines are used for pain control. They work best when used with other non-medicine treatments for pain, in combination with acetaminophen and ibuprofen. Some of these are exercise, massage, heat, ice, relaxation techniques, deep breathing, and distraction.

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